The PR500 PRISM cell set was grown with either folic acid or 5-methyl tetrahydrofolate (THF) as a folate source and treated with several methotrexate doses. Cells exposed to 5-methyl THF were found to be more resistant to methotrexate indicating that environmental folate source affects folate metabolism and response to antifolate drugs.
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PRISM will be accepting submissions for our next screen May 27 – June 13!
DMSO-soluble small molecules (single agent and combination format) and single agent antibodies, ADCs, and growth-inhibiting cytokines will be accepted for our 930 cancer cell line screen.
