Publications

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Yu C, et al. Nature Biotechnology, 2016

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

Corsello SM, et al. Nature Cancer, 2020

Targeting ROS production through inhibition of NADPH oxidases

Reis J, et al. Nature Chemical Biology, 2023

Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities

Chang L, et al. Nature Genetics, 2023

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

Baumgartner C, et al. Nature, 2023

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

Abbott K, et al. Cell Chemical Biology, 2023

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

Lu W, et al. Journal of Medicinal Chemistry, 2023

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Li Q, et al. Cancer Discovery, 2022

Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation

You I, et al. Cell Chemical Biology, 2022

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

Boehnke N & Straehla JP, et al. Science, 2022

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Sullivan MR, et al. Nature Metabolism, 2021

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

Dhimolea E, et al. Cancer Cell, 2021

A metastasis map of human cancer cell lines

Jin X, et al. Nature, 2020

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

Kinker GS, et al. Nature Genetics, 2020

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

McFarland JM, et al. Nature Communications, 2020

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

Schauer NJ, et al. Scientific Reports, 2020

Mitochondrial metabolism promotes adaptation to proteotoxic stress

Tsvetkov P, et al. Nature Chemical Biology, 2019

The landscape of cancer cell line metabolism

Li H, et al. Nature Medicine, 2019

Conference Abstracts