A panel of 253 PRISM cell lines were cultured in 2D and 3D conditions for 15 days with chemotherapy treatment. 3D cultures retained >10% viability whereas 2D cultures fell to <0.1%. Overall this study showed that CDK9 inhibition enhances chemosensitivity in Myc-suppressed, chemo-persistent cells.
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PRISM will be accepting submissions for our next screen May 27 – June 13!
DMSO-soluble small molecules (single agent and combination format) and single agent antibodies, ADCs, and growth-inhibiting cytokines will be accepted for our 930 cancer cell line screen.
