Submit to the PRISM MTS026 screen April 29 – May 17!

We are now accepting DMSO-soluble single agents for our 930 cancer cell line screen. Contact our team to learn more.

Publications

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Yu C, et al. Nature Biotechnology, 2016

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

Corsello SM, et al. Nature Cancer, 2020

Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Pichavaram P, et al. Molecular Cancer Therapeutics, 2024

Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase

Maw JJ, et al. Journal of Medicinal Chemistry, 2024

A Benzarone Derivative Inhibits EYA to Suppress Tumor Growth in SHH Medulloblastoma

Hwang G, et al. Cancer Research, 2024

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma

Hofman DA, et al. Molecular Cell, 2024

Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers

Payton M, et al. Nature Cancer, 2023

Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers

Dufva O, et al. Immunity, 2023

Targeting ROS production through inhibition of NADPH oxidases

Reis J, et al. Nature Chemical Biology, 2023

Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities

Chang L, et al. Nature Genetics, 2023

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

Baumgartner C, et al. Nature, 2023

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

Abbott K, et al. Cell Chemical Biology, 2023

Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors

Lu W, et al. Journal of Medicinal Chemistry, 2023

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors

Li Q, et al. Cancer Discovery, 2022

Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation

You I, et al. Cell Chemical Biology, 2022

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

Boehnke N & Straehla JP, et al. Science, 2022

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Sullivan MR, et al. Nature Metabolism, 2021

An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

Dhimolea E, et al. Cancer Cell, 2021

A metastasis map of human cancer cell lines

Jin X, et al. Nature, 2020

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

Kinker GS, et al. Nature Genetics, 2020

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism

Schauer NJ, et al. Scientific Reports, 2020

Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action

McFarland JM, et al. Nature Communications, 2020

Mitochondrial metabolism promotes adaptation to proteotoxic stress

Tsvetkov P, et al. Nature Chemical Biology, 2019

The landscape of cancer cell line metabolism

Li H, et al. Nature Medicine, 2019

Conference Abstracts